Actualités en direct des projets (non traduites)

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February is almost upon us, and with it, PrimeGrid's annual Tour de Primes. This is a month long event where all can earn special Tour de Primes badges and a lucky few will win the coveted Tour de Primes jerseys. More information can be found here.

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Création : 31 janvier 2024

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This afternoon PrimeGrid experienced an unplanned outage. For reasons unknown, the database locked up and started consuming 100% CPU on all 32 cores, while doing nothing at all. We proceeded cautiously, not wanting to risk damaging the database, and slowly shut down the system, checked the database, and brought everything back up. Everything is back to normal, and the servers are operating once again.

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Création : 27 janvier 2024

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The time has come to inform you about what will happen next with the Universe@Home project.

As you know, Krzysztof Belczyński was the initiator and lead scientist of the project - he was the head of our small team. His sudden passing caused a bit of chaos, which we are gradually trying to manage. Unfortunately, the latest changes in the application code that were being implemented also disappeared with him. For this reason, as well as the necessity to introduce changes to the application code that had been planned for some time, we have decided to temporarily suspend the generation of new WUs.

As of today, we already know that Universe@Home will not end - it is being taken under the wing of Prof. Tomasz Bulik (https://nauka-polska.pl/#/profile/scientist?id=23855⟨=en&_k=ta6rhj). Nevertheless, we must ask for your patience; at this moment, the most important thing is to manage the organizational and formal matters and to work on the changes in the code. This should take us two to three months.

I will keep you updated.

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Création : 26 janvier 2024

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Dear all, we have obtained results for different targets of SARS-CoV-2. The computations continue, and we want to ask your opinion on the next target. You can vote for one of them until February 5th, 2024.

• SARS-CoV-2 main protease (3CLpro) further studies
  
  This is a crucial therapeutic target against SARS-CoV-2. 3CLpro (cysteine protease; EC 3.4.22.69) in particular is crucial for the cleavage of coronavirus polyproteins to form mature non-structural proteins that are themselves essential for viral replication mechanisms. We still need much more research on this target towards new more potent inhibitors.
  
  
• Ebolavirus glycoprotein (GP)
  
  Ebola virus is a dangerous pathogen to humans and this target could be a perfect study case for PPI-type drug design scenario. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion.
  
  
• Swine acute diarrhea syndrome coronavirus (SADS-CoV PLpro)
  
  This target would enable us to study the design on multiple related viral targets. Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. The pathogen indicates towards host-jump potential.

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Création : 26 janvier 2024

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There were a lot of notification issues since 14th while the project email account was blocked. A small change today fixed it including UOTD.

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Création : 23 janvier 2024

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Part 2 of the 10^21 search will be over some time in March this year, so it's time to start getting ready for part 3! I found a few bugs in the current GPU applications that needed to be fixed (CPU applications are fine).

To make sure everything works as intended, I will launch a small beta-test of the part 3 search by the end of this week. The new work units will require ~2.5-2.7 GB RAM on CPU, and the same amount of RAM on GPU (for GPU applications), so the minimum requirement for GPUs will be 3 GB RAM.

The purpose of the test is to confirm that all OS/CPU/GPU combinations work properly and confirm that 3 GB GPUs can process the new work units.

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Création : 22 janvier 2024